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Services

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For Prokaryotic Genome Assembly & Annotation Service, send your files via this google form- https://forms.gle/z4QYLm9RdFobGj699

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For Molecular Dynamics Simulation Service, send your files via this google form- https://forms.gle/yKjXth9XqrZRWaBz9

Research Areas

-Development of Artificial Intelligence-based tools  for disease diagnosis
-Development of Biological databases and software
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Prokaryotic & eukaryotic genome assembly & annotation pipeline development
-16s rRNA and shotgun metagenomic data analysis pipeline development
-RNA-Seq data analysis pipeline development
-Exploration of the human and mouse gut microbiome
-Anti-microbial drug & vaccine development
-Anti-diabetic compounds exploration 
-SARS-CoV-2 transmissibility analysis and therapeutics development
-Breast cancer therapeutics development

Our Publications

[1]M. Hossain et al., “Towards finding the linkage between metabolic and age-related disorders using semantic gene data network analysis,” Bioinformation, vol. 12, no. 1, pp. 22–27, Jan. 2016, doi: https://doi.org/10.6026/97320630012022.
[2]M. U. Hossain et al., “Treating Diabetes Mellitus: Pharmacophore Based Designing of Potential Drugs fromGymnema sylvestreagainst Insulin Receptor Protein,” BioMed Research International, vol. 2016, pp. 1–14, 2016, doi: https://doi.org/10.1155/2016/3187647.
[3]M. U. Hossain, A. R. Oany, S. A. I. Ahmad, Md. A. Hasan, Md. A. Khan, and M. A. A. Siddikey, “Identification of potential inhibitor and enzyme-inhibitor complex on trypanothione reductase to control Chagas disease,” Computational Biology and Chemistry, vol. 65, pp. 29–36, Dec. 2016, doi: https://doi.org/10.1016/j.compbiolchem.2016.10.002.
[4]M. U. Hossain, A. Hashem, C. A. Keya, and Md. Salimullah, “Therapeutics Insight with Inclusive Immunopharmacology Explication of Human Rotavirus A for the Treatment of Diarrhea,” Frontiers in Pharmacology, vol. 7, Jun. 2016, doi: https://doi.org/10.3389/fphar.2016.00153.
[5]M. U. Hossain et al., “Finding Potential Therapeutic Targets against Shigella flexneri through Proteome Exploration,” Frontiers in Microbiology, vol. 7, Nov. 2016, doi: https://doi.org/10.3389/fmicb.2016.01817.
[6]M. Salimullah, “Sorting Out Non-Synonymous Single Nucleotide Polymorphism Leads to Novel Biomarker Discovery for Disease Prognosis,” Current Trends in Biomedical Engineering & Biosciences, vol. 3, no. 2, Apr. 2017, doi: https://doi.org/10.19080/ctbeb.2017.03.555608.
[7]M. U. Hossain et al., “Design of peptide-based epitope vaccine and further binding site scrutiny led to groundswell in drug discovery against Lassa virus,” 3 Biotech, vol. 8, no. 2, Jan. 2018, doi: https://doi.org/10.1007/s13205-018-1106-5.
[8]M. U. Hossain et al., “An Immunopharmacoinformatics Approach in Development of Vaccine and Drug Candidates for West Nile Virus,” Frontiers in Chemistry, vol. 6, Jul. 2018, doi: https://doi.org/10.3389/fchem.2018.00246.
[9]M. U. Hossain et al., “Pathway based therapeutic targets identification and development of an interactive database CampyNIBase of Campylobacter jejuni RM1221 through non-redundant protein dataset,” PLOS ONE, vol. 13, no. 6, p. e0198170, Jun. 2018, doi: https://doi.org/10.1371/journal.pone.0198170.
[10]Md. Moniruzzaman et al., “Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population,” Molecular Genetics & Genomic Medicine, vol. 8, no. 2, Dec. 2019, doi: https://doi.org/10.1002/mgg3.1073.
[11]A. Bhattacharjee et al., “Insight of druggable cannabinoids against estrogen receptor β in breast cancer,” Journal of Biomolecular Structure & Dynamics, pp. 1–10, Mar. 2020, doi: https://doi.org/10.1080/07391102.2020.1737233.
[12]M. Moniruzzaman et al., “Coding-Complete Genome Sequence of SARS-CoV-2 Isolate from Bangladesh by Sanger Sequencing,” Microbiology Resource Announcements, vol. 9, no. 28, Jul. 2020, doi: https://doi.org/10.1128/mra.00626-20.
[13]M. Jahan et al., “Genomic Surveillance of SARS-CoV-2 Viruses Collected during the Ending Phase of the First Wave of the COVID-19 Pandemic in Bangladesh,” Microbiology Resource Announcements, vol. 10, no. 29, p. e0049621, Jul. 2021, doi: https://doi.org/10.1128/MRA.00496-21.
[14]A. Rahman et al., “Unveiling ancestral relations, host–pathogen interactions and comparative viral miRNA insights of dengue virus serotypes,” Network Modeling Analysis in Health Informatics and Bioinformatics, vol. 10, no. 1, Apr. 2021, doi: https://doi.org/10.1007/s13721-021-00297-4.
[15]“Recognition of plausible therapeutic agents to combat COVID-19: An omics data based combined approach,” Gene, vol. 771, p. 145368, Mar. 2021, doi: https://doi.org/10.1016/j.gene.2020.145368.
[16]M. U. Hossain et al., “Novel mutations in NSP-1 and PLPro of SARS-CoV-2 NIB-1 genome mount for effective therapeutics,” Journal of Genetic Engineering and Biotechnology, vol. 19, no. 1, Apr. 2021, doi: https://doi.org/10.1186/s43141-021-00152-z.
[17]I. Ahammad et al., “Wave-wise comparative genomic study for revealing the complete scenario and dynamic nature of COVID-19 pandemic in Bangladesh,” PLOS ONE, vol. 16, no. 9, p. e0258019, Sep. 2021, doi: https://doi.org/10.1371/journal.pone.0258019.
[18]M. Uzzal Hossain et al., “Whole genome sequencing for revealing the point mutations of SARS-CoV-2 genome in Bangladeshi isolates and their structural effects on viral proteins,” RSC Advances, vol. 11, no. 61, pp. 38868–38879, 2021, doi: https://doi.org/10.1039/D1RA05327B.
[19]M. U. Hossain et al., “Protein-protein interactions network model underlines a link between hormonal and neurological disorders,” Informatics in Medicine Unlocked, vol. 28, p. 100866, Jan. 2022, doi: https://doi.org/10.1016/j.imu.2022.100866.
[20]S. S. Ahmed et al., “Virtual screening reveals liquiritigenin as a broad-spectrum inhibitor of SARS-CoV-2 variants of concern: an in silico study,” Journal of Biomolecular Structure and Dynamics, pp. 1–19, Aug. 2022, doi: https://doi.org/10.1080/07391102.2022.2111361.
[21]Z. M. Chowdhury et al., “Exploration of Streptococcus core genome to reveal druggable targets and novel therapeutics against S. pneumoniae,” PLOS ONE, vol. 17, no. 8, p. e0272945, Aug. 2022, doi: https://doi.org/10.1371/journal.pone.0272945.
[22]A. Bhattacharjee, I. Ahammad, Z. M. Chowdhury, K. C. Das, C. A. Keya, and Md. Salimullah, “Proteome-Based Investigation Identified Potential Drug Repurposable Small Molecules Against Monkeypox Disease,” Molecular Biotechnology, Nov. 2022, doi: https://doi.org/10.1007/s12033-022-00595-w.
[23]A. Bhattacharjee et al., “High risk genetic variants of human insulin receptor substrate 1(IRS1) infer structural instability and functional interference,” Journal of Biomolecular Structure & Dynamics, pp. 1–15, Mar. 2023, doi: https://doi.org/10.1080/07391102.2023.2187232.
[24]Abdullah Al‐Mamun et al., “Pharmacoinformatics and molecular dynamics simulation approach to identify anti-diarrheal potentials of Centella asiatica (L.) Urb. against Vibrio cholerae,” Journal of Biomolecular Structure & Dynamics, pp. 1–14, Mar. 2023, doi: https://doi.org/10.1080/07391102.2023.2191736.
[25]Ishtiaque Ahammad et al., “Impact of highly deleterious non-synonymous polymorphisms on GRIN2A protein’s structure and function,” PLOS ONE, vol. 18, no. 6, pp. e0286917–e0286917, Jun. 2023, doi: https://doi.org/10.1371/journal.pone.0286917.
[26]Ishtiaque Ahammad, Zeshan Mahmud Chowdhury, A. Bhattacharjee, Sheikh Sunzid Ahmed, F. Akter, and Md Salimullah, “Structure-based pharmacological screening, molecular docking and dynamic simulation reveals Dexketoprofen as a repurposable drug against Alzheimer’s disease,” Informatics in Medicine Unlocked, pp. 101380–101380, Oct. 2023, doi: https://doi.org/10.1016/j.imu.2023.101380.
[27]Mohammad Uzzal Hossain et al., “Investigation of pathogenic germline variants in gastric cancer and development of ‘GasCanBase’ database,” Cancer reports, Oct. 2023, doi: https://doi.org/10.1002/cnr2.1906.

[28]Zeshan Mahmud Chowdhury et al., “Identification of repurposable drug targets in Mycoplasma pneumoniae using subtractive genomics, molecular docking and dynamics simulation,” Heliyon, pp. e21466–e21466, Nov. 2023, doi: https://doi.org/10.1016/j.heliyon.2023.e21466.

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